MARC Record from marc_columbia

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008 111010s2012 flua ob 000 0 eng d
010 $a 2011033944
035 $a(OCoLC)ocn756484229
035 $a(NNC)15083000
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020 $a9781439839140$q(electronic)
020 $a143983914X$q(electronic)
020 $a9781283274531
020 $a1283274531
020 $a9780429064128$q(e-book ;$qPDF)
020 $a0429064128
020 $a9781138114821$q(paperback)
020 $a1138114820
020 $z9781439839133
020 $z1439839131
024 7 $a10.1201/b11234$2doi
035 $a(OCoLC)756484229$z(OCoLC)756898106$z(OCoLC)759865882$z(OCoLC)778614993$z(OCoLC)816864257$z(OCoLC)872321466$z(OCoLC)879853897$z(OCoLC)1004623676$z(OCoLC)1011946714$z(OCoLC)1044605746$z(OCoLC)1056414331$z(OCoLC)1060841542$z(OCoLC)1065649676$z(OCoLC)1069705090$z(OCoLC)1077419767$z(OCoLC)1084332572$z(OCoLC)1110591569$z(OCoLC)1179423233$z(OCoLC)1224923752$z(OCoLC)1240531329
037 $aCL0500000430$bSafari Books Online
050 4 $aQR84.8 S76 2011
060 4 $aQU 55.9
072 7 $aPNR$2bicssc
082 04 $a572.6$a612/.01575
049 $aZCUA
245 00 $aThermostable proteins :$bstructural stability and design /$c[edited by] Srikanta Sen, Lennart Nilsson.
260 $aBoca Raton, Fla. :$bCRC Press,$c©2012.
300 $a1 online resource (xix, 153. [17] pages) :$billustrations
336 $atext$btxt$2rdacontent
337 $acomputer$bc$2rdamedia
338 $aonline resource$bcr$2rdacarrier
520 $a"Thermostable Proteins: Structural Stability and Design provides a comprehensive, updated account of the physical basis of enhanced stability of thermophilic proteins and the design of tailor-made thermostable proteins, paving the way for their possible industrial applications. This book is devoted to understanding the survival mechanisms of "thermophilic life forms" at the molecular level with an emphasis on design strategies. The review chapters presented in Thermostable Proteins span a wide range of protein thermostability research. Basic structural, thermodynamic, and kinetic principles are explained and molecular strategies for the adaptation to high temperatures are delineated. In addition, this book covers: computing and simulation methods in current and future thermostability research, especially in nonempirical situations, how rigidity theory is used to improve the thermal adaptation of mesophiles Subtilisin-like serine proteases and their significant engineering applications. The state of knowledge concerning structure function relations and the origins of their structural stability. Computational and experimental approaches for the design of proteins with increased thermal stability based on sequences or three-dimensional structures. Understanding the molecular basis of how thermostable and hyperthermostable proteins gain and maintain their stability and biological function at high temperatures remains an important scientific challenge. A more detailed knowledge of protein stability not only deepens our understanding of protein structure but also helps in obtaining insights into processes that drive protein activities folding, unfolding, and misfolding essential to biological function"--Provided by publisher.
504 $aIncludes bibliographical references.
505 0 $aDelineation of the conformational thermostability of hyperthermophilic proteins based on structural and biophysical analyses / Atsushi Mukaiyama, Kazufumi Takano -- Role of packing, hydration, and fluctuations on thermostability / Fabio Sterpone, Simone Melchionna -- Analyzing protein rigidity for understanding and improving thermal adaptation / Doris L. Klein, Sebastian Radestock, Holger Gohlke -- Thermostable subtilases (subtilisin-like serine proteinases) / Magnús M. Kristjánsson -- Combined computational and experimental approaches to sequence-based design of protein thermal stability / Julie C. Mitchell [and others] -- Designing thermophilic proteins: a structure-based computational approach / Sohini Basu, Srikanta Sen.
588 0 $aPrint version record.
650 0 $aProtein engineering.
650 0 $aProteins$xAnalysis.
650 0 $aProteins$xConformation.
650 0 $aThermodynamics.
650 12 $aProtein Stability
650 22 $aProtein Conformation
650 22 $aThermodynamics
650 2 $aProtein Engineering
650 6 $aTechnologie des protéines.
650 6 $aProtéines$xAnalyse.
650 6 $aProtéines$xConformation.
650 6 $aThermodynamique.
650 7 $athermodynamics.$2aat
650 7 $aProtein engineering.$2fast$0(OCoLC)fst01079685
650 7 $aProteins$xAnalysis.$2fast$0(OCoLC)fst01079714
655 0 $aElectronic books.
655 4 $aElectronic books.
700 1 $aSen, Srikanta.
700 1 $aNilsson, Lennart,$d1952 November 11-
776 08 $iPrint version:$aSen, Srikanta.$tThermostable Proteins : Structural Stability and Design.$dHoboken : CRC Press, ©2011$z9781439839133
856 40 $uhttp://www.columbia.edu/cgi-bin/cul/resolve?clio15083000$zTaylor & Francis eBooks
852 8 $blweb$hEBOOKS