| Record ID | marc_dnb_202006/dnb_all_dnbmarc_20200615-4.mrc:2940401:5927 |
| Source | Deutsche Nationalbibliothek |
| Download Link | /show-records/marc_dnb_202006/dnb_all_dnbmarc_20200615-4.mrc:2940401:5927?format=raw |
LEADER: 05927nam a2200721uc 4500
001 1134883277
003 DE-101
005 20200215102741.0
007 cr||||||||||||
008 170608s2013 gw |||||o|||| 00||||eng
015 $a17,O07$2dnb
016 7 $2DE-101$a1134883277
024 7 $a10.1242%2Fbio.20134614$2doi
024 7 $2urn$aurn:nbn:de:bsz:25-freidok-119366
035 $a(DE-599)DNB1134883277
035 $a(OCoLC)992999541
040 $a1240$bger$cDE-101$d9999$erda
041 $aeng
044 $cXA-DE-BW
082 74 $88\p$a616.079$qDE-101$223kdnb
083 7 $89\p$a610$qDE-101$223sdnb
100 1 $0(DE-588)1121216145$0https://d-nb.info/gnd/1121216145$0(DE-101)1121216145$aBensch, Robert$d1982-$eVerfasser$4aut$2gnd
245 10 $aNon-directional radial intercalation dominates deep cell behavior during zebrafish epiboly
264 1 $aFreiburg$bUniversität$c2013
300 $aOnline-Ressource
336 $aText$btxt$2rdacontent
337 $aComputermedien$bc$2rdamedia
338 $aOnline-Ressource$bcr$2rdacarrier
500 $aBiology open. 2, 8 (2013), 845-854, DOI 10.1242%2Fbio.20134614, issn: 2046-6390
500 $aIN COPYRIGHT http://rightsstatements.org/page/InC/1.0 rs
520 $aAbstract: Epiboly is the first coordinated cell movement in most vertebrates and marks the onset of gastrulation. During zebrafish epiboly, enveloping layer (EVL) and deep cells spread over the vegetal yolk mass with a concomitant thinning of the deep cell layer. A prevailing model suggests that deep cell radial intercalations directed towards the EVL would drive deep cell epiboly. To test this model, we have globally recorded 3D cell trajectories for zebrafish blastomeres between sphere and 50% epiboly stages, and developed an image analysis framework to determine intercalation events, intercalation directionality, and migration speed for cells at specific positions within the embryo. This framework uses Voronoi diagrams to compute cell-to-cell contact areas, defines a feature-based spatio-temporal model for intercalation events and fits an anatomical coordinate system to the recorded datasets. We further investigate whether epiboly defects in MZspg mutant embryos devoid of Pou5f1/Oct4 may be caused by changes in intercalation behavior. In wild-type and mutant embryos, intercalations orthogonal to the EVL occur with no directional bias towards or away from the EVL, suggesting that there are no directional cues that would direct intercalations towards the EVL. Further, we find that intercalation direction is independent of the previous intercalation history of individual deep cells, arguing against cues that would program specific intrinsic directed migration behaviors. Our data support a dynamic model in which deep cells during epiboly migrate into space opening between the EVL and the yolk syncytial layer. Genetic programs determining cell motility may control deep cell dynamic behavior and epiboly progress
583 1 $aArchivierung/Langzeitarchivierung gewährleistet$5DE-101$2pdager
650 7 $81\p$0(DE-588)4026637-0$0https://d-nb.info/gnd/4026637-0$0(DE-101)040266370$aImmunologie$2gnd
650 7 $82\p$0(DE-588)4026643-6$0https://d-nb.info/gnd/4026643-6$0(DE-101)040266435$aImmunsystem$2gnd
650 7 $83\p$0(DE-588)4036762-9$0https://d-nb.info/gnd/4036762-9$0(DE-101)040367622$aLymphozyt$2gnd
650 7 $84\p$0(DE-588)4074195-3$0https://d-nb.info/gnd/4074195-3$0(DE-101)040741958$aLeukozyt$2gnd
650 7 $85\p$0(DE-588)4120476-1$0https://d-nb.info/gnd/4120476-1$0(DE-101)04120476X$aImmunität$gMedizin$2gnd
650 7 $86\p$0(DE-588)4136408-9$0https://d-nb.info/gnd/4136408-9$0(DE-101)041364082$aResistenz$2gnd
650 7 $87\p$0(DE-588)4161366-1$0https://d-nb.info/gnd/4161366-1$0(DE-101)04161366X$aImmunchemie$2gnd
653 $a(local)article
700 1 $0(DE-588)1121237150$0https://d-nb.info/gnd/1121237150$0(DE-101)1121237150$aSong, Sungmin$eVerfasser$4aut$2gnd
700 1 $aRonneberger, Olaf$eVerfasser$4aut
700 1 $0(DE-588)108175074X$0https://d-nb.info/gnd/108175074X$0(DE-101)108175074X$aDriever, Wolfgang$d1960-$eVerfasser$4aut$2gnd
710 2 $0(DE-588)1300564-9$0https://d-nb.info/gnd/1300564-9$0(DE-101)943903688$aAlbert-Ludwigs-Universität Freiburg$bInstitut für Informatik$eMitwirkender$4ctb
710 2 $0(DE-588)1082777579$0https://d-nb.info/gnd/1082777579$0(DE-101)1082777579$aAlbert-Ludwigs-Universität Freiburg$bCentre for Biological Signalling Studies$eMitwirkender$4ctb
710 2 $0(DE-588)1130794482$0https://d-nb.info/gnd/1130794482$0(DE-101)1130794482$aAlbert-Ludwigs-Universität Freiburg$bEntwicklungsbiologie$eMitwirkender$4ctb
710 2 $0(DE-588)1111901015$0https://d-nb.info/gnd/1111901015$0(DE-101)1111901015$aSpemann Graduate School of Biology and Medicine$eMitwirkender$4ctb
710 2 $0(DE-588)2024338-8$0https://d-nb.info/gnd/2024338-8$0(DE-101)004816633$aAlbert-Ludwigs-Universität Freiburg$eVerlag$4pbl
850 $aDE-101a$aDE-101b
856 40 $uhttps://doi.org/10.1242%2Fbio.20134614$xResolving-System
856 40 $uhttps://nbn-resolving.org/urn:nbn:de:bsz:25-freidok-119366$xResolving-System
856 0 $uhttps://d-nb.info/1134883277/34$xLangzeitarchivierung Nationalbibliothek
856 4 $qzip$uhttps://freidok.uni-freiburg.de/data/11936$zkostenfrei
883 0 $81\p$amaschinell gebildet$c1$d20190524$qDE-101
883 0 $82\p$amaschinell gebildet$c1$d20190524$qDE-101
883 0 $83\p$amaschinell gebildet$c1$d20190524$qDE-101
883 0 $84\p$amaschinell gebildet$c1$d20190524$qDE-101
883 0 $85\p$amaschinell gebildet$c1$d20190524$qDE-101
883 0 $86\p$amaschinell gebildet$c1$d20190524$qDE-101
883 0 $87\p$amaschinell gebildet$c1$d20190524$qDE-101
883 0 $88\p$amaschinell gebildet$c0,75248$d20180813$qDE-101
883 0 $89\p$amaschinell gebildet$c0,945$d20170609$qDE-101
925 r $aro$arb