MARC Record from Library of Congress

LEADER: 03078cam a22003374a 4500
001 2010032106
003 DLC
005 20110518083410.0
008 100804s2011 nyua b 001 0 eng
010 $a 2010032106
020 $a9780199559046 (hbk. : alk. paper)
035 $a(DNLM)101537515
040 $aDNLM/DLC$cDLC$dDLC
042 $apcc
050 00 $aQP551$b.S535 2011
082 00 $a612.8$222
100 1 $aSherwood, Dennis.
245 10 $aCrystals, X-rays, and proteins :$bcomprehensive protein crystallography /$cDennis Sherwood, Jon Cooper.
260 $aNew York :$bOxford University Press,$c2011.
300 $axvii, 621 p. :$bill. ;$c26 cm.
500 $aUpdate to: Crystals, X-rays, and proteins / Dennis Sherwood. 1976.
504 $aIncludes bibliographical references and index.
505 8 $aMachine generated contents note: -- 1. The crystalline state and its study2. Vector analysis and complex algebra3. Crystal systematics4. Waves and electromagnetic radiation5. Fourier transforms and convolutions6. Diffraction7. Diffraction from one-dimensional obstacles8. Diffraction from a three-dimensional lattice9. The contents of the unit cell10. Experimental methods: sample preparatio11. Experimental techniques: data collection and analysis12. The Phase problem and the Patterson function13. Molecular replacement14. Solving the phase problem experimentally15. Refinement16. Complementary crystallographic methods.
520 $a"A complete account of the theory of the diffraction of x-rays by crystals with particular reference to the processes of determining the structures of protein molecules, this book is aimed primarily at structural biologists and biochemists but will also be valuable to those entering the field with a background in physical sciences or chemistry. It may be used at any post-school level, and develops from first principles all relevant mathematics, diffraction and wave theory, assuming no mathematical knowledge beyond integral calculus. The book covers a host of important topics in the area, including:- The practical aspects of sample preparation and x-ray data collection, using both laboratory and synchrotron sources - Data analysis at both theoretical and practical levels- The important role played by the Patterson function in structure analysis by both molecular replacement and experimental phasing approaches - Methods for improving the resulting electron density map - The theoretical basis of methods used in refinement of protein crystal structures - In-depth explanation of the crucial task of defining the binding sites of ligands and drug molecules - The complementary roles of other diffraction methods which reveal further detail of great functional importance in a crystal structure"--Provided by publisher.
650 0 $aProteins$xStructure.
650 0 $aX-ray crystallography.
650 12 $aProteins$xchemistry.
650 22 $aCrystallography, X-Ray$xmethods.
650 22 $aProtein Conformation.
700 1 $aCooper, Jon$q(Jonathan B.)
700 1 $aSherwood, Dennis.$tCrystals, X-rays, and proteins.