MARC Record from Library of Congress

LEADER: 05087cam a22004217a 4500
001 2010937423
003 DLC
005 20150129081441.0
008 100920s2011 nyua b 001 0 eng
010 $a 2010937423
016 7 $a101550692$2DNLM
016 7 $a015694880$2Uk
020 $a9781603271868 (alk. paper)
020 $a1603271864 (alk. paper)
020 $a9781607618492 (e-ISBN)
020 $a1607618494 (e-ISBN)
035 $a(OCoLC)ocn678514802
040 $aNLM$cNLM$dHNC$dCUS$dCOU$dIXA$dMIA$dUKMGB$dDLC
042 $anlmcopyc$alccopycat
050 00 $aRM301.25$b.D7864 2011
060 00 $aW1$bME9616J v.691 2011
060 10 $aQV 771
245 00 $aDrug safety evaluation :$bmethods and protocols /$cedited by Jean-Charles Gautier.
260 $aNew York, NY :$bHumana Press,$cc2011.
300 $axiii, 431 p. :$bill. (some col.) ;$c26 cm.
490 1 $aMethods in molecular biology,$x1064-3745 ;$v691
490 1 $aSpinger protocols
504 $aIncludes bibliographical references and index.
505 0 $aPart I. General toxicology. Developing combination drugs in preclinical studies / Alberto Lodola. Preclinical evaluation of juvenile toxicity / Paul C. Barrow, Stéphane Barbellion, and Jeanne Stadler -- Part II. Pathology. Necropsy and sampling procedures in rodents / Laurence Fiette and Mohamed Slaoui. Histopathology procedures : from tissue sampling to histopathological evaluation / Mohamed Slaoui and Laurence Fiette. Principles and methods of immunohistochemistry / José A. Ramos-Vara. Tissue microarrays and digital image analysis / Denise Ryan, Laoighse Mulrane, Elton Rexhepaj, and William M. Gallagher -- Part III. Genetic toxicology. Micronucleus assay and labeling of centromeres with FISH technique / Ilse Decordier, Raluca Mateuca, and Micheline Kirsch-Volders. The use of bacterial repair endonucleases in the comet assay / Andrew R. Collins -- Part IV. Safety pharmacology. Manual whole-cell patch-clamping of the HERG cardiac K⁺ channel / Xiao-Liang Chen, Jiesheng Kang, and David Rampe -- Part V. Investigative toxicology. Generation and analysis of transcriptomics data / Philip D. Glaves and Jonathan D. Tugwood. Protocols of two-dimensional difference gel electrophoresis to investigate mechanisms of toxicity / Emmanuelle Com, Albrecht Gruhler, Martine Courcol, and Jean-Charles Gautier. Protocols and applications of cellular metabolomics in safety studies using precision-cut tissue slices and carbon 13 NMR / Gabriel Baverel, Sophie Renault, Hassan Faiz, Maha El Hage, Catherine Gauthier, Agnès Duplany, Bernard Ferrier, and Guy Martin. Statistical analysis of quantitative RT-PCR results / Richard Khan-Malek and Ying Wang. Evaluation of mitochondrial respiration in cultured rat hepatocytes / Jean-Pierre Marchandeau and Gilles Labbe -- Part VI. Screening assays for developmental toxicity. FETAX assay for evaluation of developmental toxicity / Isabelle Mouche, Laure Malesic, and Olivier Gillardeaux. Evaluation of embryotoxicity using the zebrafish model / Lisa Truong, Stacey L. Harper, and Robert L. Tanguay -- Part VII. Chemical protein adducts. Protocols of in vitro protein covalent binding studies in liver / Jean-François Lévesque, Stephen H. Day, and Allen N. Jones. Utilization of MALDI-TOF to determine chemical-protein adduct formation in vitro / Ashley A. Fisher, Matthew T. Labenski, Terrence J. Monks, and Serrine S. Lau. Utilization of LC-MS/MS analyses to identify site-specific chemical protein adducts in vitro / Ashley A. Fisher, Matthew T. Labenski, Terrence J. Monks, and Serrine S. Lau. One-dimensional western blotting coupled to LC-MS/MS analysis to identify chemical-adducted proteins in rat urine / Matthew T. Labenski, Ashley A. Fisher, Terrence J. Monks, and Serrine S. Lau. Identification of chemical-adducted proteins in urine by multi-dimensional protein identification technology (LC/LC-MS/MS) / Matthew T. Labenski, Ashley A. Fisher, Terrence J. Monks, and Serrine S. Lau -- Part VIII. Safety biomarkers. Optimization of SELDI for biomarker detection in plasma / Jean-Francois Léonard, Martine Courcol, and Jean-Charles Gautier. Differential proteomics incorporating iTRAQ labeling and multi-dimensional separations / Ben C. Collins, Thomas Y.K. Lau, Stephen R. Pennington, and William M. Gallagher. NMR and MS methods for metabonomics / Frank Dieterle, Björn Riefke, Götz Schlotterbeck, Alfred Ross, Hans Senn, and Alexander Amberg. Absolute quantification of toxicological biomarkers by multiple reaction monitoring / Thomas Y. K. Lau, Ben C. Collins, Peter Stone, Ning Tang, William M. Gallagher, and Stephen R. Pennington.
650 0 $aDrugs$xToxicology.
650 0 $aDrugs$xTesting.
650 12 $aDrug Evaluation, Preclinical$xmethods.
650 22 $aDrug Toxicity.
650 22 $aToxicity Tests$xmethods.
700 1 $aGautier, Jean-Charles.
830 0 $aMethods in molecular biology (Clifton, N.J.) ;$x1064-3745$vv. 691.
830 0 $aSpringer protocols.
856 41 $3CDC subscription E-book$uhttp://elib2.cdc.gov:3273/BookToc/doi/10.1007/978-1-60761-849-2