MARC Record from Library of Congress

LEADER: 02816cam a2200421 i 4500
001 2012554149
003 DLC
005 20150213081633.0
008 130430t20132013enka b 001 0 eng
010 $a 2012554149
016 7 $a016171898$2Uk
020 $a9780199670512 (hbk)
020 $a019967051X (hbk)
020 $a9780199670529 (pbk.)
020 $a0199670528 (pbk.)
035 $a(OCoLC)ocn835079607
040 $aAU@$beng$cAU@$erda$dOCLCO$dCDX$dUOH$dBTCTA$dUKMGB$dYDXCP$dCUD$dBWX$dIUL$dOCLCF$dMUU$dOCLCQ$dDLC
042 $alccopycat
050 00 $aQD477$b.C69 2013
082 04 $a546.24$223
100 1 $aCox, Brian G.
245 10 $aAcids and bases :$bsolvent effects on acid-base strength /$cBrian G. Cox, AstraZeneca Macclesfield, UK.
250 $aFirst edition.
264 1 $aOxford :$bOxford University Press,$c2013.
264 4 $c©2013
300 $axii, 143 pages :$billustrations ;$c25 cm
336 $atext$btxt$2rdacontent
337 $aunmediated$bn$2rdamedia
338 $avolume$bnc$2rdacarrier
504 $aIncludes bibliographical references and index.
505 0 $a1. Introduction -- 2. Acid-base equilibria: quantitative treatment -- 3. Solvation and acid-base strength -- 4. Determination of dissociation constants -- 5. Protic solvents -- 6. High-basicity polar aprotic solvents -- 7. low-basicity and low-polarity aprotic solvents -- 8. Acid-base equilibria and salt formation -- 9. Appendices: dissociation constants in methanol and aprotic solvents.
520 $aAcids and bases are ubiquitous in chemistry. Our understanding of them, however, is dominated by their behaviour in water. Transfer to non-aqueous solvents leads to profound changes in acid-base strengths and to the rates and equilibria of many processes: for example, synthetic reactions involving acids, bases and nucleophiles; isolation of pharmaceutical actives through salt formation; formation of zwitter-ions in amino acids; and chromatographic separation of substrates. This book seeks to enhance our understanding of acids and bases by reviewing and analysing their behaviour in non-aqueous solvents. The behaviour is related where possible to that in water, but correlations and contrasts between solvents are also presented. Fundamental background material is provided in the initial chapters: quantitative aspects of acid-base equilibria, including definitions and relationships between solution pH and species distribution; the influence of molecular structure on acid strengths; and acidity in aqueous solution.--$cSource other than Library of Congress.
650 0 $aSolvents.
650 0 $aAcids.
650 0 $aBases (Chemistry)
650 7 $aAcids.$2fast$0(OCoLC)fst00795828
650 7 $aBases (Chemistry)$2fast$0(OCoLC)fst00828067
650 7 $aSolvents.$2fast$0(OCoLC)fst01125677