MARC Record from Library of Congress

LEADER: 02881cam a22004577a 4500
001 2012554527
003 DLC
005 20140917190834.0
008 130614m20129999maua b 000 0 eng
010 $a 2012554527
016 7 $a101591108$2DNLM
016 7 $a016129606$2Uk
020 $a9781573318730 (v. 1257)
020 $a1573318736 (v. 1257)
020 $a9781573318730 (v. 1258)
020 $a1573318922 (v. 1258)
020 $a9781573318921 (v. 1258)
035 $a(OCoLC)ocn808441505
040 $aNLM$beng$cNLM$dGUA$dOCLCO$dYDXCP$dCUD$dBWX$dUKMGB$dNDD$dDLC
042 $anlmcopyc$alccopycat
050 00 $aQH603.C4$bB37 2012
050 14 $aQ11$b.N533b v. 1257-1258
060 00 $aW1$bAN626YL v.1257-1258 2012
060 10 $aQU 350
082 04 $a571.6$223
245 00 $aBarriers and channels formed by tight junction proteins /$cissue editors, Michael Fromm, Jörg-Dieter Schulzke.
260 $aBoston, Mass. :$bPublished by Wiley-Blackwell Pub. on behalf of the New York Academy of Sciences,$c2012-
300 $av. <1-2> :$bill. ;$c26 cm.
490 1 $aAnnals of the New York Academy of Sciences,$x0077-8923 ;$vv. 1257-1258
500 $aCaption title.
504 $aIncludes bibliographical references.
520 $a"Tight junctions between epithelial and endothelial cells form selective barriers and paracellular channels and regulate paracellular transport of solutes, immune cells, and drugs. More specifically, tight junctions consist of proteins that laterally interconnect neighboring cells of epithelia and endothelia. Certain proteins seal the tight junction, so that a nearly impermeable barrier develops, whereas others form channels that allow for permeation between the cells. Recent investigations have focused on tight junction proteins, belonging to the claudin family (claudins-1 to -27 in humans) and the newly defined group of TAMP (three proteins: occludin, Marvel-D2, and tricellulin). Barriers and Channels Formed by Tight Junction Proteins I showcases work in this area clustered around three major themes: the molecular properties of tight junctions, for example, the role of the claudin family of proteins and the formation of ion and charge-selective channels; the regulation of tight junction and barrier functions via genetic mechanisms and scaffold protein mediation; and the functional role of the tight junction in various tissues, such as the skin, lungs, endothelia, and nervous system"--Publisher description.
530 $aAlso available online.
650 0 $aTight junctions (Cell biology)
650 12 $aTight Junctions$xphysiology.
650 22 $aClaudins$xmetabolism.
650 22 $aMembrane Proteins$xmetabolism.
700 1 $aFromm, Michael,$cDr. med.
700 1 $aSchulzke, Jörg-Dieter.
710 2 $aNew York Academy of Sciences.
830 0 $aAnnals of the New York Academy of Sciences ;$vv. 1257-1258.