MARC Record from Library of Congress

LEADER: 04413cam a22004817i 4500
001 2014397702
003 DLC
005 20141104085559.0
008 140603s2013 dcua b 100 0deng d
010 $a 2014397702
020 $a9780309290814
020 $a0309290813
035 $a(OCoLC)ocn867561314
040 $aNOC$beng$cNOC$erda$dOCLCA$dNRZ$dOCLCA$dIXA$dYDXCP$dCDX$dBTCTA$dDLC
042 $alccopycat
050 00 $aR850.A2$bO27 2013
082 00 $a610.72/4$223
110 2 $aObservational Studies in a Learning Health System (Workshop)$d(2013 :$cWashington, D.C.)
245 10 $aObservational studies in a learning health system :$bworkshop summary /$cClaudia Grossmann and Joe Alper, rapporteurs ; a Learning Health System Activity, Roundtable on Value & Science-Driven Health Care, Institute of Medicine of the National Academies.
264 1 $aWashington, D.C. :$bThe National Academies Press,$c[2013]
300 $axix, 114 pages :$billustrations (chiefly color) ;$c23 cm
336 $atext$btxt$2rdacontent
337 $aunmediated$bn$2rdamedia
338 $avolume$bnc$2rdacarrier
500 $a"Observational Studies in a Learning Health System: an Institute of Medicine workshop, sponsored by the Patient-Centered Outcomes Research Institute; a Learning Health System Activity, IOM Roundtable on Value & Science-Driven Health Care, April 25-26, 2013, National Academy of Sciences"--Page 101.
520 $a"Clinical research strains to keep up with the rapid and iterative evolution of medical interventions, clinical practice innovation, and the increasing demand for information on the clinical effectiveness of these advancements. In response to the growing availability of archived and real-time digital health data and the opportunities this data provides for research, as well as the increasing number of studies using prospectively collected clinical data, the Institute of Medicine's Roundtable on Value & Science-Driven Health Care convened a workshop on Observational Studies in a Learning Health System. Participants, including experts from a wide range of disciplines - clinical researchers, statisticians, biostatisticians, epidemiologists, health care informaticians, health care analytics, research funders, health products industry, clinicians, payers, and regulators - explored leading edge approaches to observational studies, charted a course for the use of the growing health data utility, and identified opportunities to advance progress. Workshop speakers and individual participants strove to identify stakeholder needs and barriers to the broader application of observational studies. Observational Studies in a Learning Health System is the summary of the workshop. This report explores the role of observational studies in the generation of evidence to guide clinical and health policy decisions. The report discusses concepts of rigorous observational study design and analysis, emerging statistical methods, and opportunities and challenges of observational studies to complement evidence from experimental methods, treatment heterogeneity, and effectiveness estimates tailored toward individual patients"--Publisher's description.
504 $aIncludes bibliographical references.
505 0 $aIntroduction -- Issues overview for observational studies in clinical research -- Engaging the issue of bias -- Generalizing randomized clinical trial results to broader populations -- Detecting treatment-effect heterogeneity -- Predicting individual responses -- Strategies going forward -- Common themes for progress.
650 0 $aClinical medicine$xResearch$vCongresses.
650 0 $aExperimental design$vCongresses.
650 0 $aEvidence-based medicine$vCongresses.
650 0 $aMedical care$vCongresses.
650 12 $aObservational Study as Topic$xmethods.
650 12 $aResearch Design$xstandards.
650 22 $aProspective Studies.
650 22 $aData Collection$xmethods.
650 22 $aDelivery of Health Care$xmethods.
650 22 $aEvidence-Based Medicine$xmethods.
700 1 $aGrossmann, Claudia,$d1978-$eauthor.
700 1 $aAlper, Joe,$eauthor.
710 2 $aInstitute of Medicine (U.S.).$bRoundtable on Value & Science-Driven Health Care,$eissuing body.
710 2 $aPatient-Centered Outcomes Research Institute (U.S.),$esponsoring body.
856 41 $3National Academies Press$uhttp://www.nap.edu/catalog.php?record_id=18438