MARC Record from Library of Congress

LEADER: 02341nam a22003258a 4500
001 2009037093
003 DLC
005 20090924134709.0
008 090904s2010 nju b 001 0 eng
035 $a(DNLM)101514620
010 $a 2009037093
020 $a9780470293423 (cloth)
040 $aDNLM/DLC$cDLC
042 $apcc
050 00 $aRC523$b.B24 2010
060 10 $aWT 155$bB117 2010
082 00 $a618.97/6831$222
245 00 $aBACE :$blead target for orchestrated therapy of Alzheimer's disease /$c[edited by] Varghese John.
260 $aHoboken, N.J. :$bJohn Wiley & Sons,$cc2010.
263 $a1004
300 $ap. ;$ccm.
504 $aIncludes bibliographical references and index.
505 0 $aBACE : APP processing, and signal transduction in Alzheimer's disease (AD) / Dale E. Bredesen and Edward H. Koo -- Identification of BACE as an AD target / Robert L. Heinrikson and Sukanto Sinha -- BACE biological assays / Alfredo G. Tomasselli and Michael J. Bienkowski -- Peptidic, peptidomimetic, and HTS based BACE inhibitors / James P. Beck and Dustin J. Mergott -- Fragment-based approaches for identification of BACE inhibitors / Andreas Kuglstatter and Michael Hennig -- Structure-based drug design of BACE inhibitors : technical and practical aspects of preparation, 3-dimensional structure, and computational analysis / Felix F. Vajdos, Veer Shanmugasundaram, and Alfredo G. Tomasselli -- Pharmacological models for preclinical testing : from mouse to dog to non-human primates / Jason L. Eriksen, Michael Paul Murphy, and Elizabeth Head -- Adsorption, distribution, metabolism, excretion (ADME), efficacy & toxicology for BACE inhibitors / Ishrut Hussain and Emmanuel Demont -- Clinical trials for disease modifying drugs such as BACE inhibitors / Henry Hsu -- Future strategies for development of novel BACE inhibitors : anti-APP e-site antibody & APP binding small molecule approaches for Alzheimer's disease / Beka Solomon ... [et al.].
650 0 $aAlzheimer's disease$xChemotherapy.
650 0 $aAspartic proteinases$xInhibitors$xTherapeutic use.
650 0 $aAmyloid beta-protein precursor.
650 12 $aAlzheimer Disease$xdrug therapy.
650 22 $aAmyloid Precursor Protein Secretases$xpharmacology.
650 22 $aAmyloid Precursor Protein Secretases$xtherapeutic use.
700 1 $aJohn, Varghese,$d1958-