MARC Record from Library of Congress

LEADER: 04643cam a22005054a 4500
001 2009921196
003 DLC
005 20110301100132.0
008 090121s2009 nyua b 001 0 eng c
010 $a 2009921196
016 7 $a101508511$2DNLM
020 $a9781603273169 (hbk. : alk. paper)
020 $a1603273166 (hbk. : alk. paper)
020 $a9781603273176 (e-ISBN)
020 $a1603273174 (e-ISBN)
035 $a(OCoLC)ocn310400809
040 $aNLM$cNLM$dBTCTA$dYDXCP$dSCB$dBWX$dCUS$dCDX$dPUL$dDLC$dIG#$dCOD$dSTF$dZWZ$dGEBAY$dDLC
042 $apcc
060 00 $aW1$bME9616J v.552 2009
060 10 $aQU 25$bG1111 2009
050 00 $aQP552.G16$bG1746 2009
245 00 $aG protein-coupled receptors in drug discovery /$cedited by Wayne R. Leifert.
260 $aNew York :$bHumana Press,$cc2009.
300 $axi, 376 p. :$cill. ;$c27cm.
490 1 $aMethods in molecular biology ;$v552
490 1 $aSpringer protocols
504 $aIncludes bibliographical references and index.
505 00 $tNew insights into GPCR function: implications for HTS /$rR.M. Eglen and T. Reisine --$tScreening technologies for G protein-coupled receptors: from HTS to uHTS /$rM. De los Frailes and E. Diez --$tGPCR signaling: understanding the pathway to successful drug discovery /$rC. Williams and S.J. Hill --$tAn overview on GPCRs and drug discovery: structure-based drug design and structural biology on GPCRs /$rK. Lundstrom --$tUnderstanding the ligand-receptor-G protein ternary complex for GPCR drug discovery /$rV.R. Ratnala and B. Kobilka --$tAssay data quality assessment /$rH. Gubler --$tHomology modeling of GPCRs /$rJ. Simms ... [et al.] --$tGPCR expression using baculovirus-infected Sf9 cells /$rA.L. Aloia ... [et al.] --$tRadioligand binding assays: application of [(125)I]angiotensin II receptor binding /$rW.R. Leifert ... [et al.] --$t[35S]GTPgammaS binding in G protein-coupled receptor assays /$rT. Cooper, E.J. McMurchie and W.R. Leifert --$tA time-resolved fluorescent lanthanide (Eu)-GTP binding assay for chemokine receptors as targets in drug discovery /$rJ. Labrecque, R.S. Wong and S.P. Fricker --$tUse of the DiscoveRx Hit hunter cAMPII assay for direct measurement of cAMP in Gs and Gi GPCRs /$rJ. Bradley and D. McLoughlin --$tUse of aequorin for G protein-coupled receptor hit identification and compound profiling /$rS.J. Brough and P. Shah --$tBacMam: versatile gene delivery technology for GPCR assays /$rE.A. Davenport, P. Nuthulaganti and R.S. Ames --$tYeast assays for G protein-coupled receptors /$rS.J. Dowell and A.J. Brown --$tGPCR microspot assays on solid substrates /$rY. Fang and J. Lahiri --$tResonant waveguide grating biosensor for whole-cell GPCR assays /$rY. Fang, A.M. Ferrie and E. Tran --$tFRET-based measurement of GPCR conformational changes /$rS. Granier ... [et al.] --$tFLIPR assays of intracellular calcium in GPCR drug discovery /$rK.B. Hansen and H. Brauner-Osborne --$tUse of fluorescence indicators in receptor ligands /$rK.G. Harikumar and L.J. Miller --$tApplication of fluorescence resonance energy transfer techniques to establish ligand-receptor orientation /$rK.G. Harikumar and L.J. Miller --$tDetection of GPCR/beta-arrestin interactions in live cells using bioluminescence resonance energy transfer technology /$rM. Kocan and K.D. Pfleger --$tUsing reporter gene technologies to detect changes in cAMP as a result of GPCR activation /$rD.J. Rodrigues and D. McLoughlin --$tA quantum dot-labeled ligand-receptor binding assay for G protein-coupled receptors contained in minimally purified membrane nanopatches /$rJ.L. Swift, M.C. Burger and D.T. Cramb --$tXenopus oocyte electrophysiology in GPCR drug discovery /$rK.B. Hansen and H. Brauner-Osborne --$tImmunoprecipitation and phosphorylation of G protein-coupled receptors /$rW.G. Thomas.
650 0 $aG proteins$xReceptors.
650 0 $aDrug development.
650 12 $aReceptors, G-Protein-Coupled$vLaboratory Manuals.
650 22 $aDrug Discovery$vLaboratory Manuals.
650 7 $aProtéines G$xRécepteurs.$2ram
650 7 $aPharmacie$xRecherche.$2ram
650 07 $aArzneimittelforschung$2swd
650 07 $aWirkstoff$2swd
650 07 $aScreening$2swd
650 07 $aG-Proteine$2swd
650 07 $aRezeptor$2swd
650 07 $aUntersuchungsmethode$2swd
700 1 $aLeifert, Wayne R.
830 0 $aMethods in molecular biology (Clifton, N.J.) ;$vv. 552.
830 0 $aSpringer protocols.
856 41 $uhttp://www.springerlink.com/content/978-1-60327-316-9
856 41 $zAvailable to Stanford-affiliated users at:$uhttp://www.springerprotocols.com/BookToc/doi/10.1007/978-1-60327-317-6