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LEADER: 02566nam 2200253Ka 4500
008 000000s2006 nyu s 000 0 eng d
040 $aTEFOD$cTEFOD
006 m d
007 cr cn---------
020 $a3805578628 (electronic bk. : Adobe Digital Editions)
037 $bOverDrive, Inc.$nhttp://www.overdrive.com
100 1 $aKabelitz, Dieter $q(Dieter Kabelitz).
245 10 $aMechanisms of Epithelial Defense$h[electronic resource].
260 $aMuenchen :$bKarger,$c2006.
500 $aTitle from eBook information screen.
520 $aEpithelial defense against infectious agents relies on the recognition of microbial products by pattern recognition receptors and the local production of antimicrobial peptides.This book provides a state-of-the-art overview of the basic characteristics and clinical relevance of antimicrobial peptides, with special emphasis on their role in skin, intestinal and lung inflammation. The evolutionary significance of antimicrobial peptides is highlighted by an in-depth analysis of their structure, activity and gene regulation in Drosophila melanogaster.Toll-like receptors are an important class of pattern recognition receptors, whose roles in recognizing bacterial molecular patterns and in the intracellular signalling pathways involved in the differentiation and function of dendritic cells are discussed. Finally, this book also addresses the role of intraepithelial lympho cytes in epithelial defense, notably of gammadelta T cells which form a link between innate and adaptive immune responses. The combined analysis of epithelial and lymphoid cells and effector mechanisms sheds new light on the epithelial defense system in physiological and pathophysiological conditions. Immunologists, dermatologists, microbiologists, and infectious disease specialists will greatly benefit from the wealth of new findings presented by leading investigators.
533 $aElectronic reproduction.$bMuenchen :$cKarger,$d2006.$nRequires Adobe Digital Editions (file size: 2031 KB).
538 $aRequires Adobe Digital Editions (file size: 2031 KB).
653 #0 $aMedical
653 #0 $aNonfiction
655 7 $aElectronic books.$2local
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