| Record ID | marc_university_of_toronto/uoft.marc:5595145856:1893 |
| Source | University of Toronto |
| Download Link | /show-records/marc_university_of_toronto/uoft.marc:5595145856:1893?format=raw |
LEADER: 01893cam 2200205 a 4500
008 050127s2004 onc b 000 0 eng d
020 $a9780494220764
100 1 $aWong, Christine Jaye
245 10 $aInsulin-like growth factor I (IGF I) in the red spotted newt, Notophthalmus viridescens: Description of larval limb development; localization of IGF I in larval and adult newt limbs; and effects of IGF I on epimorphic regeneration of an adult newt appendage in vitro.
260 $c2004.
300 $a202 leaves.
502 $aThesis (Ph.D.) -- University of Toronto, 2004.
504 $aIncludes bibliographical references.
506 $aElectronic version licesed for access by U. of T. users.
520 $aThis study initiates research into the effects of IGF I on epimorphic appendage regeneration in the adult newt, Notophthalmus viridescens. As regeneration in this animal is often considered a recapitulation of development, the current research compares the expression of IGF I in developing larval forelimbs and regenerating adult forelimbs. To facilitate this comparison, a description of larval forelimb development was undertaken. This thesis is the first comprehensive record staging limb development in N. viridescens. In addition to the morphological descriptions, whole-mount and histological analyses of cellular development were made. This study determined that IGF I is a naturally occurring growth factor in this animal's liver, as observed among many vertebrates. ...
650 0 $aNotophthalmus viridescens.
650 2 $aInsulin-Like Growth Factor I.
856 41 $uhttp://proquest.umi.com/pqdweb?did=1264606051&sid=1&Fmt=2&clientId=12520&RQT=309&VName=PQD
949 $atheses CSBIO 2004 Ph.D. 12931$wLC$c1$i31761073470098$lTHESES$mGERSTEIN$rY$sY$tTHESIS$u16/11/2007
949 $atheses CSBIO 2004 Ph.D. 12931$wLC$c1$i6252728-3001$lMICROTEXT$mMEDIA_COMM$rN$sY$tMICROFORM$u16/11/2007