Mechanisms of ventilator-induced lung injury.

Mechanisms of ventilator-induced lung injury.
Ian Copland, Ian Copland
Not in Library

My Reading Lists:

Create a new list

Check-In

×Close
Add an optional check-in date. Check-in dates are used to track yearly reading goals.
Today


Buy this book

Last edited by WorkBot
January 22, 2010 | History

Mechanisms of ventilator-induced lung injury.

Despite its life-saving potential, mechanical ventilation is associated with significant preventable lung injury. In an effort to better understand the mechanisms of ventilator-induced lung injury (VILI), I profiled changes in lung gene and inflammatory mediator expressions in vivo using adult and newborn rat models of volutrauma and then identified the intracellular signaling for developmentally conserved mediators using an in vitro stretch system. Results of these studies demonstrate that the lung responds to high-tidal volume (HV) ventilation with a robust pro-inflammatory response that occurs prior to the onset of physiologic injury. Newborn lungs are less susceptible to the injurious effects of high-tidal volume then adult lungs. A distinct set of early response mediators (genes, proteins, lipids) represents a developmentally conserved mechanism through which lung cells respond to HV ventilation. Specifically, the Egr1, MIP-2 and Cox-2 mRNA responses to stretch are developmentally conserved as are the PGI2 and TXB 2 eicosanoid responses. Mechanistically, these mediators are controlled by distinct and overlapping signaling pathways that are all hierarchically integrated at a stretch-induced influx of extracellular calcium.

Publish Date
Language
English
Pages
236

Buy this book

Edition Availability
Cover of: Mechanisms of ventilator-induced lung injury.
Mechanisms of ventilator-induced lung injury.
2005
in English

Add another edition?

Book Details


Edition Notes

Source: Dissertation Abstracts International, Volume: 66-10, Section: B, page: 5233.

Thesis (Ph.D.)--University of Toronto, 2005.

Electronic version licensed for access by U. of T. users.

The Physical Object

Pagination
236 leaves.
Number of pages
236

ID Numbers

Open Library
OL21302853M
ISBN 10
0494077166

Community Reviews (0)

Feedback?
No community reviews have been submitted for this work.

Lists

This work does not appear on any lists.

History

Download catalog record: RDF / JSON
January 22, 2010 Edited by WorkBot add more information to works
December 11, 2009 Created by WorkBot add works page