An edition of Beyond the Blockbuster Drug (2005)

Beyond the Blockbuster Drug

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Last edited by Serge Gailly
July 26, 2015 | History
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An edition of Beyond the Blockbuster Drug (2005)

Beyond the Blockbuster Drug

by

About the Book
The blockbuster model now delivers just 5% return on investment and only one in six new drug prospects will deliver returns above their cost of capital, as a result competitive pressures and falling R&D productivity will instigate a new pharmaceutical model that replaces the unsustainable blockbuster model; personalized medicine and the "nichebuster" (in this book, Gilbert Mertens coined the term “nichebuster”).
This report, Beyond the Blockbuster Drug: Strategies for nichebuster drugs, targeted therapies and personalized medicine, examines targeted therapies and targeted drug delivery strategies as alternative investment options for pharmaceutical companies, in the face of declining returns and slow growth in the blockbuster market. This report’s strategic insight is also supported by in-depth interviews with thought leaders from the pharmaceutical industry, providing you with their insight into how tomorrow’s pharmaceutical business model will develop. This report analyzes the niche pharmaceutical sectors with the greatest potential for profit and future growth. Harness the technological advances in personalized medicine and be part of the "nichebuster" revolution set to drive market growth and produce the market leading drugs of tomorrow.

Publish Date
Publisher
Reuters Business Insight, London
Language
English

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Edition Availability
Cover of: Beyond the Blockbuster Drug
Beyond the Blockbuster Drug
2005, Reuters Business Insight, London
Paperback in English

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Book Details

Table of Contents

Table of Contents
Beyond the blockbuster drug: Strategies for nichebuster drugs, targeted therapies and personalized medicine.
Acknowledgements 8
Executive summary 14
The blockbuster: An unsustainable model 14
Industry at a crossroads 15
Beyond the blockbuster: Personalized medicine 15
Targeted medicine: oncology 16
New drug technologies: discovery and delivery 17
Drug development: outsourcing and partnering 18
Case study: Roche 19
Case study: Novartis 20
Creating tomorrow�s winning company 21
Chapter 1 The blockbuster: An
unsustainable model 24
Summary 24
Introduction 25
The rise and fall of the blockbuster phenomenon 27
The blockbuster phenomenon 27
When blockbusters come off patent 29
Implications for the future of the industry 31
Chapter 2 The industry at a crossroads 34
Summary 34
The Failure of R&D 34
The R&D performance gap 38
The failure of the "mega-merger" 41
Conclusion 44
Chapter 3 Beyond the blockbuster:
Personalized medicine 48
Summary 48
Where next? 49
Personalized medicine 51
Gene-based therapies reach the market by 2010 51
The race for new therapies 53
Conclusion 55
Chapter 4 Targeted medicine: Oncology 58
Summary 58
Introduction 59
A promising therapeutic field 61
Gleevec 61
Therapeutic focus on cancer 62
Drug discovery deals 63
Molecularly targeted therapies 66
Herceptin 67
Promising treatments for breast cancer 69
Advances in treatment for colorectal cancer 70
Prostate cancer 70
Conclusion 71
Chapter 5 Targeted drug delivery 76
Summary 76
New drug technologies 78
Customized medicine 79
A future of unseen opportunity 80
Advances in science 81
Targeted drug delivery 82
Oral delivery of macromolecules 83
Enhanced bioavailability / Efflux inhibitors 83
SCF technologies 84
Inhibiting P-gp action 84
Injectable, biodegradable depot drug delivery 85
Parenteral drug delivery 85
PEGylation to deliver protein and cancer drugs 86
Conclusion 87
Chapter 6 Drug development: Outsourcing
and partnering 90
Summary 90
Introduction 91
Why outsource? 91
The changing CRO model 92
Biotechs are reshaping drug development 93
Moving from vendor to strategic partner 93
Realizing strategic value 94
The ideal CRO model for the new outsourcing paradigm 96
Models for outsourcing 97
Do-it-yourself 97
Architect 97
Integrated design and build 98
Risk-sharing 98
Conclusion 99
Chapter 7 Case study: Roche 102
Summary 102
Banking on "nichebusters" 102
A radically transformed Roche portfolio 103
Diagnostics: An essential precursor for targeted medicines 104
R&D partnerships for faster growth 106
Conclusion 107
Chapter 8 Case study: Novartis 110
Summary 110
Targeted medicine 110
Breadth vs depth? 111
Novartis portfolio 112
PTK787 (ZX 222584) 112
ICL670 113
Gimatecan 113
Femara 114
Conclusion 115
Beyond targeted medicine 115
Chapter 9 Creating tomorrow�s winning
company 120
Summary 120
Prisoners of ROI 121
Adding a dimension to the matrix 121
Pharmaceutical companies as service providers 122
Boom times knocking at the door.. 123
� But not without change 124
Alliances fuel innovation 125
Growing a product to its maximum sales 126
Medicines for "My" body 127
A broader view of the competition 128
Far-reaching psychological and structural transformation 129
Conclusion 131
Index 132
Figures
Figure 1.1: From therapy to health maintenance busters 26
Figure 2.2: Emergence of an elite group of R&D spenders 35
Figure 2.3: Ten year evolution of a drug�s development cost 36
Figure 2.4: Declining R&D success* 37
Figure 2.5: Drug candidates of major R&D-driven pharma companies 38
Figure 2.6: Performance gap in R&D 39
Figure 2.7: Breakdown of projects by clinical phase and source of drug 40
Figure 2.8: No economies of scale in pharmaceutical R&D 42
Figure 2.9: Shareholder returns of merged and non-merged companies 44
Figure 2.10: The need for alliances and partnering 45
Figure 3.11: Genomic research based products reach the market before 2010 52
Figure 3.12: Genetically manufactured substances in the pipeline 53
Figure 4.13: Therapeutic focus of clinical pipeline activity 62
Figure 4.14: Global oncology players, 2002 63
Figure 4.15: Deals by therapeutic focus (Sept �02 t0 Mar �04) 64
Figure 4.16: Therapeutic focus by company (Sept �02 to Mar �04) 65
Figure 4.17: Development of the global oncology market 2001-2008* 66
Figure 4.18: Breast cancer market opportunities 69
Figure 6.19: Today�s R&D environment 92
Figure 6.20: The future R&D environment 96
Figure 7.21: Leading products in the Roche portfolio, 2003 103
Figure 7.22: The Roche business model: Innovation and diagnostics 104
Table 8.23: Novartis, sales by type of business activity ($m), 2003 111
Figure 8.24: External sources contribute to Novartis� product growth 115
Figure 9.25: Drug discovery holds immense possibilities 126
Figure 9.26: Reshaping the "traditional" healthcare model 128
Figure 9.27: The integrated virtual MegaPharma-Biotech company 130
List of Tables
Table 3.1: Drug candidates in early stage clinical development, 2002-2003 54
Table 4.2: Cancer pathologies (selected) in the US 60
Table 5.3: Novel drug technologies 78
Table 7.4: Roche: Early stage development alliances 107
Table 8.5: Estimated product launch timetable for Novartis� drug pipeline 114

Edition Notes

Published in
London, UK

Contributors

Contributor
Hatsumo Aoki, Mariana Brea-Krüger, Anand Burma, Barry Clare, Jocelyne Coupat, Gunter Festel, Spiros Fotinos, Tugrul T. Kararli, Daniel Keesman, Volker Keidtel, Douglas J. Squires, Peter Zuendorf

The Physical Object

Format
Paperback

ID Numbers

Open Library
OL24606662M

Work Description

See the description "about the book".

In this book, Gilbert Mertens, a renowed strategic thinker, coined the term "nichebusters". In 2000, he already came up with facts and figures about the declining blockbuster sales of medicines (those medicines that reach sales of at least US $ 1 billion) and the need for the pharmaceutical industry to adapt to reality, to change its business model...it took the industry ten years to follow his advise

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July 26, 2015 Edited by Serge Gailly Added a description of the book
October 21, 2011 Edited by George undo merge authors
October 13, 2011 Edited by Michèle Varda merge authors
February 18, 2011 Edited by Ilse Andiel, MD Added new cover
February 18, 2011 Created by Ilse Andiel, MD Added new book.