Correspondence, diary notes, memoranda, minutes of meetings, reports, speeches, statements, writings, notes, press releases, press conference transcripts, annotated press reports, briefing books, advertising material, and photographs chiefly documenting Safire's close association with Richard M. Nixon as public relations consultant, speechwriter, and political advisor from 1960 to 1973. Includes material relating to Nixon's 1960 presidential campaign, the 1966 general elections, the 1968 presidential campaign, and especially to Safire's role on the Nixon White House staff prior to the Watergate affair. Also includes material on Safire's work on Louis J. Lefkowitz's 1961 New York City mayoral campaign, Jacob K. Javits's 1962 senate race, Nelson A. Rockefeller's 1964 presidential bid and 1966 New York gubernatorial reelection, and other Republican campaigns; drafts and notes for his retrospective writings about the Nixon administration; and material relating to his works on political terminology and lexicography.

Other persons represented include Spiro T. Agnew, Patrick J. Buchanan, Arthur F. Burns, Charles W. Colson, John Ehrlichman, H. R. Haldeman, Thomas Huston, Henry Kissinger, Daniel P. Moynihan, Richard Nathan, Raymond K. Price, William P. Rogers, and George Pratt Schultz.