Family and general correspondence, subject and business files, and personal financial papers relating primarily to Pulitzer's editorship of the St. Louis Post-Dispatch and contain material on nearly every aspect of the operation and production of the newspaper, including its working philosophy, internal business management, and editorial policies. Includes extensive files of correspondence between Pulitzer and his editorial and reporting staffs and other journalists, as well as his correspondence with local St. Louis and national government officials. There is also extensive material relating to his personal and family life and to his great interest in hunting and fishing. Other topics include Pulitzer's interest in Nazi concentration camps, Joseph Pulitzer, Sr., the Pulitzer estate, and the administration of the Pulitzer Prize.

Correspondents include Paul Y. Anderson, Bernard M. Baruch, Oliver Kirby Bovard, Raymond P. Brandt, Richard Evelyn Byrd, Norman Chandler, Marquis William Childs, James Bryant Conant, Raymond L. Crowley, Dwight Filley Davis, Frederick Trubee Davison, Irving Dilliard, Cyrus Stephen Eaton, Ernest Gruening, Jesse H. Jones, David Lawrence, Walter Lippmann, Agnes Elizabeth Ernst Meyer, Eugene Meyer, Ogden Livingston Mills, Charles Nagel, Adolph S. Ochs, Joseph Medill Patterson, Benjamin Harrison Reese, Charles G. Ross, Franklin D. Roosevelt, Wesley Winans Stout, Arthur Hays Sulzberger, Herbert Bayard Swope, Stuart Symington, Norman Thomas, Arthur H. Vandenberg, Oswald Garrison Villard, Sumner Welles, and John N. Wheeler.