Claire is at the start of her medical career when she falls in love with Addison Boehning, a biochemist with blazing genius and big dreams. A complicated pregnancy forces Claire to drop out of her residency, which she never completes after Jory is born. Addison's discovery of a test for ovarian cancer catapults the young family to wealth beyond their wildest dreams. They purchase an extravagant Seattle home, and a fixer-upper second home in a small Washington town. But when Addison bets everything on a cutting-edge cancer drug, and loses, life dramatically changes for the family. They must leave their plush lifestyle behind and live in the second home while Addison tries to salvage his reputation and his lab, and Claire must take a job at a struggling public health clinic.