Correspondence, memoranda, notes and drafts for speeches, legal papers, invitations, printed matter, newspaper clippings, and other papers pertaining to Webster's New Hampshire and Massachusetts law practices and cases heard before the U.S. Supreme Court, the Bank of the United States, diplomacy, the Northeast boundary dispute, opposition to the Mexican War, Latin American relations, national and state politics, slavery, the Compromise of 1850 (including notes for Webster's speech of 7 March 1850), the tariff question, public opinion of the presidential administrations of John Quincy Adams and Andrew Jackson, development of the anti-Masonic movement, Webster's presidential aspirations, and his role as secretary of state in the administrations of John Tyler and Millard Fillmore. Webster's early life is described in letters (1849) from Charles Archer to James Watson Webb, editor of the New York Courier and Enquirer.

Correspondents include Lord Ashburton (Alexander Baring), George Edmund Badger, Daniel D. Barnard, Nicholas Biddle, Lewis Cass, Rufus Choate, Henry Clay, Charles Pelham Curtis, Lord Dalling and Bulwer (Sir Henry Lytton Bulwer), John Davis, Edward Everett, Millard Fillmore, Joseph Hopkinson, James Kent, Abbott Lawrence, James K. Mills, Viscount Ossington (John Evelyn Denison), Isaac Parker, Josiah Quincy, Richard Rush, Jared Sparks, Ambrose Spencer, Andrew Stevenson, John Tyler, Fletcher Webster, Noah Webster, and Henry Wheaton.