Through this review article, “Neural Supernova”, a new hypothesis to explain the aetiology of Schizophrenia is proposed. According to this hypothesis, high levels of dopamine may result from excessive biosynthesis of the amino acid tyrosine, the precursor to dopamine. Possible mutagenesis of tryptophan synthetase or calmodulin, and low Mg2+ and high Fe2+, may also result in “Neural Supernova”, which is the rapid metabolic breakdown of glucose in the brain causing psychosis and ischemia.