An edition of Quantitative modeling in toxicology
(2010)
Quantitative modeling in toxicology
by Kannan Krishnan and Melvin E. Andersen
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"In Quantitative Modeling in Toxicology leading experts outline the current state of knowledge on the modeling of dose, tissue interactions and tissue responses. Each chapter describes the mathematical foundation, parameter estimation, challenges and perspectives for development, along with the presentation of a modeling template. Additionally, tools and approaches for conducting uncertainty, sensitivity and variability analyses in these models are described"--Provided by publisher.
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Quantitative Modeling in Toxicology
2010, Wiley & Sons, Incorporated, John
in English
1282689584 9781282689589
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Book Details
Table of Contents
Machine generated contents note: Preface
About the Editors
About the Book
List of Contributors
Section1: Introduction
Chapter 1 Quantitative modeling in toxicology: An introduction
Melvin E. Andersen and Kannan Krishnan
Section2: Physiologically-based toxicokinetic and pharmacokinetic (PBPK) modeling
Chapter 2 PBPK modeling: a primer
Kannan Krishnan, George Loizou, Martin Spendiff, John Lipscomb and Melvin E. Andersen
Chapter 3 Pharmacokinetic modeling with Manganese - An essential element
Andy Nong, Michael Taylor, Miyoung Yoon, and Melvin E. Andersen
Chapter 4 Physiologically-based modeling of pharmacokinetic interactions in chemical mixtures
Sami Haddad, Robert Tardif, Jonathan Boyd, and Kannan Krishnan
Chapter 5 Physiological Parameters and Databases for PBPK Modeling
Douglas O. Johns, Elizabeth Oesterling Owens, Chad M. Thompson, Babasaheb Sonawane, Dale Hattis and Kannan Krishnan
Section3: Modeling toxicant-target interactions
Chapter 6 Modeling cholinesterase Inhibition
Charles Timchalk, Paul M. Hinderliter,and Torka S. Poet
Chapter 7 Modeling of Protein Induction and dose-dependent hepatic sequestration
Andy Nong and Melvin E. Andersen
Chapter 8 Bistable Signaling Motifs and Cell Fate Decisions
Sudin Bhattacharya, Qiang Zhang, and Melvin E. Andersen M.E.
Chapter 9 Ultrasensitive Response Motifs in Biochemical Networks
Qiang Zhang, Sudin Bhattacharya, Courtney G. Woods, and Melvin E. Andersen
Chapter 10 Gene and Protein Expression - Modeling Nested Motifs in Cellular and Tissue Response Networks
Melvin E. Andersen, Qiang Zhang, and Sudin Bhattacharya
Chapter 11 Modeling Kidney and Liver Cytotoxicity
Kai H. Liao, Yu-Mei Tan, Harvey J. Clewell III, and Melvin E. Andersen
Section4: Modeling tissue and organism responses
Chapter 12 Computational Model for Iodide Economy and the HPT Axis in the Adult Rat
Jeffrey W. Fisher and Eva D. McLanahan
Chapter 13 Two Stage Clonal Growth Modeling of Cancer
Rory B. Conolly and Melvin E. Andersen
Chapter 14 Statistical and Physiological Modeling of the Toxicity of Chemicals in Mixtures
Hisham A. El-Masri, Michael A. Lyons, and Raymond S.H. Yang
Chapter 15 (Q)SAR Models of Adverse Responses: Acute Systemic Toxicity
Mark T.D. Cronin, Yana K. Koleva, and Judith C. Madden
Section5: Model application and evaluation
Chapter 16 Modeling Exposures to Chemicals from Multiple Sources and Routes
Panos G. Georgopoulos, Sastry S. Isukapalli, and Kannan Krishnan
Chapter 17 Probabilistic Reverse Dosimetry Modeling for Interpreting Biomonitoring Data
Yu-Mei Tan and Harvey J. Clewell III
Chapter 18 Quantitative Modeling in Noncancer Risk Assessment
Q. Jay Zhao, Lynne Haber, Melissa Kohrman., Patricia Nance, and Michael Dourson
Chapter 19 Application of Physiologically Based Pharmacokinetic Modeling in Risk Assessment
Harvey J. Clewell III
Chapter 20 Uncertainty, Variability and Sensitivity Analyses in Simulation Models
Sastry S. Isukapalli, Martin Spendiff, Panos G. Georgopoulos and Kannan Krishnan
Chapter 21 Evaluation of Quantitative Models in Toxicology: Progress and challenges
Kannan Krishnan and Melvin E. Andersen.
Edition Notes
Includes bibliographical references and index.
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| September 29, 2021 | Edited by ImportBot | import existing book |
| July 28, 2014 | Created by ImportBot | import new book |