Julie Jenson, a single thirty-eight-year-old book publicist in New York, gets a hysterical phone call from her friend Georgia. Reeling from her husband's announcement that he is leaving her, Georgia convinces Julie to organize a fun girls' night out. But the night, which ends with a trip to the hospital, becomes a wake-up call for Julie. Fed up with the dysfunction and disappointments of being single, Julie quits her job and sets off to find out how women around the world are dealing with this dreaded phenomenon.