The letters in the first work, which were edited by Hans Kaspar Wolf, the author's literary executor, deal with botany, materia medica, and natural history, and are either addressed to eminent physicians and scientists of the day. There are references to Guaiacum, tobacco, and the New World.

Issued with: Conradi Gesneri philosophi et medici tigvrini, De aconita primo dioscoridis, asseueratio. Et eivsdem, De oxymelitis elleborati vtrivsqve descriptione & vsu libellus. Omnia partim nunc primùm, partim verò emendatiora et auctioria, per Casparvm VVolphivm tigurinum medicum in lucem data, on leaves [1]-28], 3rd count, which has separate dated title page with imprint: Anno M.D.LXXVII.

"Conradi Gesneri philosophi et medici tigvrini, De aconita primo dioscoridis, asseueratio", leaves 3 verso-20 verso, 3rd count, has separate caption title and woodcut botanical illustrations.

"Conradi Gesneri philosophi et medici, De vtroqve oxymelite ellaborato, libellus", leaves 21 recto-28 recto, 3rd count, has separate caption title.

Signatures: a⁴ (a1 verso blank) B⁴ A⁴ ²B⁴ C-Z⁴ ²a⁴ b-m⁴ 2A-2G⁴ (2G4 verso blank)

Woodcut printer's devices on title pages; initials.

Arents Tobacco Collection. Tobacco: a catalogue, II:22.

Verzeichnis der Drucke 16. / 17. Jahrhunderts (VD 16 / VD 17), G 1719.

Verzeichnis der Drucke 16. / 17. Jahrhunderts (VD 16 / VD 17), G 1693 (Aconti primi dioscoridis asservatio)

Verzeichnis der Drucke 16. / 17. Jahrhunderts (VD 16 / VD 17), G 1790 (De oxymelitis helleborati utriusque descriptione et usu)

European Americana, 577/18.

Purchase; 2016; 17-101.

Text primarily in Latin with some parts and of and some entire letters in Greek.

John Carter Brown Library copy bound in contemporary limp vellum with gold tooling; housed in a brown cloth-covered clamshell box measuring 24 cm in height.

John Carter Brown Library copy acquired with the assistance of the Sophia Augusta Brown Fund.

Provenance of the John Carter Brown Library copy: Ex libris S. Haberl: bookstamp on first title page; a bookplate partially reading "Profes ..." and Bac" has been torn off from the inside of the front limp vellum cover.