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Elastic filaments refer mainly to titin, the largest of all known proteins. Titin was discovered initially in muscle cells, where it interconnects the thick filament with the Z-line. Titin forms a molecular spring that is responsible for maintaining the structural integrity of contracting muscle, ensuring efficient muscle contraction. More recently, it has become clear that titin is not restricted to muscle cells alone. For example, titin is found in chromosomes of neurons and also in blood platelets. This topic is fast becoming a focal point for research in understanding viscoelastic properties at the molecular, cellular, and tissue levels. In titin may lie a generic basis for biological viscoelasticity. It has become clear that titin may hold the key to certain clinical anomalies. For example, it is clear that titin-based ventricular stiffness is modulated by calcium and that titin is responsible for the altered stiffness in cardiomyopathies. It is also clear from evidence from a group of Finnish families that titin mutations may underlie some muscular dystrophies and that with other mutations chromatids fail to separate during mitosis. Thus, it is clear that this protein will have important clinical implications stemming from its biomechanical role. One aspect of this field is the bringing together of bioengineers with clinical researchers and biologists. Genetic and biochemical aspects of titin-related proteins are being studied together with front-line engineering approaches designed to measure the mechanics of titin either in small aggregates or in single molecules.
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1
Elastic Filaments of the Cell: June 16-19,1999, on the campus of the University of Washington (Seattle, WA)
2012, Springer London, Limited
in English
1461542677 9781461542674
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2
Elastic filaments of the cell
2000, Kluwer Academic/Plenum Publishers
in English
0306464101 9780306464102
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3
Elastic Filaments of the Cell (Advances in Experimental Medicine and Biology)
August 31, 2000, https://link.springer.com/book/10.1007/978-1-4615-4267-4
Hardcover
in English
- 1 edition
0306464101 9780306464102
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Book Details
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Edition Notes
"Proceedings of the conference Elastic Filaments of the Cell, held June 16-19, 1999, in Seattle, Washington"--T.p. verso.
Includes bibliographical references and index.
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Feedback?July 12, 2024 | Edited by MARC Bot | import existing book |
February 5, 2023 | Edited by meot | added Karoly Trombitas |
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