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A ready-to-use guide for establishing and interrogating human and animal models of autoimmune diseases. Patr I contains methods and protocols to assess immunological and biochemical pathways relevant for disease pathogenesis. Part II contains protocols to establish and assess inflammatory arthritis, SLE, myocarditis, thyroiditis, experimental allergic encephalomyelitis (EAE, IDDM, scleroderma, uveitis, and vitiligo. All methods focus on assessment of genetic, immunological, and biochemical parameters underlying spontaneous or exogenous antigen-induced diseases.
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Autoimmunity: methods and protocols
2012, Humana Press, Springer
in English
- 2nd ed.
1607617196 9781607617198
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Book Details
Table of Contents
Pathogenesis and spectrum of autoimmunity / Andras Perl
Models of pathogenesis in human autoimmune disorders
Mapping the systematic lupus erythematosus susceptibility genes / Swapan K. Nath, John B. Harley, and R. Hal Scofield
T cell signaling abnormalities in human systemic lupus erythematosus / Madhusoodana P. Nambiar, Sandeep Krishnan, and George Tsokos
TCR chain abnormalities in human systemic lupus erythematosus / Madhusoodana P. Nambiar ... [et al.]
Protein kinase A and signal transduction in T lymphocytes : biochemical and molecular methods / Islam U. Khan and Gary M. Kammer
Apoptosis and mitochondrial dysfunction in lymphocytes of patients with systemic lupus erythematosus / Andras Perl ... [et al.]
Methods for inducing apoptosis / Kathryn M. Roberts, Antony Rosen, and Livia A. Casciola-Rosen
Measurement of cytokines in autoimmune disease / Kyriakos A. Kirou, Christina Lee, and Mary K. Crow
Evaluation of autoimmunity to transaldolase in multiple sclerosis / Brian Niland and Andras Perl
Animal models of autoimmunity
Animal models for autoimmune myocarditis and autoimmune thyroiditis / Daniela Ciháková ... [et al.]
Animal models of insulin-dependent diabetes mellitus / Edwin Liu ... [et al.]
Generation, maintenance, and adoptive transfer of diabetogenic T cell lines/clones from the nonobese diabetic mouse / Martha J. Milton ... [et al.]
Experimental use of murine lupus models / Stanford L. Peng
The anti-DNA knockin model of systemic autoimmunity induced by the chronic graft-vs-host reaction / Robert Eisenberg and Arpita Choudhury
Murine models of lupus induced by hypomethylated T cells / Bruce Richardson, Donna Ray, and Raymond Yung
The mouse model of collagen-induced arthritis / David D. Brand, Andrew H. Kang, and Edward F. Rosloniec
Proteoglycan aggrecan-induced arthritis: a murine autoimmune model of rheumatoid arthritis / Tibor T. Glant
Methods for induction and analysis of mouse models of multiple
Sclerosis : experimental autoimmune encephalomyelitis and Theiler's virus-induced demyelinating disease / Kevin G. Fuller ... [et al.]
Experimental autoimmune encephalitomyelitis / Praveen Rao and Benjamin M. Segal
Animal models of scleroderma / Gabriella Lakos, Shinsuke Takagawa, and John Varga
Rodent models of experimental autoimmune uveitis / Rajeev K. Agarwal and Rachel R. Caspi
Autoimmune depigmentation following sensitization to melanoma antigens / Arthur A. Hurwitz and Qingyong Ji.
Edition Notes
Includes bibliographical references and index.
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