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Table of Contents
Mechanisms of antisense drug action, an introduction / Stanley T. Crooke ... [et al.]
The RNase h mechanism / Walt Lima, Hongjiang Wu, Stanley T. Crooke
Small RNA silencing pathways / Alla Sigova, Phillip Zamore
Splice switching sligonucleotides as potential therapeutics / Peter Sazani, Maria A. Graziewicz, Ryszard Kole
Basic principles of antisense drug discovery / Susan M. Freier, Andrew T. Watt
The medicinal chemistry of oligonucleotides / Eric E. Swayze, Balkrishen Bhat
Basic principles of the pharmacokinetics of antisense oligonucleotide drugs / Arthur A. Levin, Rosie Z. Yu, Richard S. Geary
Routes and formulations for delivery of antisense oligonucleotides / Gregory E. Hardee, Lloyd G. Tillman, Richard S. Geary
Liposomal formulations for nucleic acid delivery / Ian MacLachlan
Pharmacological properties of 2'-O-methoxyethyl modified oligonucleotides / C. Frank Bennett
Pharmacokinetic/pharmacodynamic properties of phosphorothioate 2'-O-(2-methoxyethyl) modified antisense oligonucleotides in animals and man / Richard S. Geary ... [et al.]
Toxicologic properties of 2'-methoxyethyl chimeric antisense inhibitors in animals and man / Scott P. Henry ... [et al.]
An overview of the clinical safety experience of first and second generation antisense oligonucleotides / T. Jesse Kwoh
Manufacturing and analytical processes / Daniel C. Capaldi, Anthony N. Scozzari
Harnessing RNA interference pathways for therapeutics utilizing chemistry: chemically modified siRNAs, drug delivery systems and antagomirs / Muthiah Manoharan
Discovery and development of RNAi therapeutics / Antonin R. deFougerolles, John M. Maraganore
Optimization of second generation antisense drugs: going beyond generation 2.0 / Brett P. Monia ... [et al.]
Modulating gene function with peptide nucleic acids (PNA) / Peter E. Nielsen
Locked nucleic acid / Troels Koch, Henrik Ørum
Morpholinos / Patrick L. Iversen
Potential therapeutic applications of antisense oligonucleotides in ophthalmology / Lisa R. Grillone, Scott P. Henry
Cardiovascular therapeutic applications / Rosanne M. Crooke, Brenda F. Baker, Mark K. Wedel
Developing antisense drugs for metabolic diseases: a novel therapeutic approach / Sanjay Bhanot
Inflammatory diseases / Susan A. Gregory, James G. Karras
Antisense oligonucleotides for the treatment of cancer / Boris A. Hadaschik, Martin E. Gleave
Targeting neurological disorders with antisense oligonucleotides / Richard A. Smith, Timothy M. Miller
Mechanisms and therapeutic applications of immune modulatory oligodeoxynucleotide and oligoribonucleotide ligands for toll-like receptors / Jörg Vollmer, Arthur M. Krieg.
Edition Notes
Includes bibliographical references and index.
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