(Publisher-supplied data) The Siren's Song: This Death That Makes Life Live 1 Gerry Melino, Richard A Knight and Jean-Claude Ameisen The Origin and Evolution of Programmed Cell Death 13 Jean Claude Ameisen Cell Death in C. elegans 21 Ataman Sendoel and Michael O Hengartner Caspases and Cell Death 30 Lorraine D Hernandez, Caroline Houde, Maarten Hoek, Brent Butts, Donald W Nicholson and Huseyin Mehmet The Apoptosome: The Executioner of Mitochondria-mediated Apoptosis 37 Elisabetta Ferraro and Francesco Cecconi Caspases, Substrates and Sequential Activation 50 John G Walsh and Seamus J Martin Dismantling the Apoptotic Cell 60 Paula Deming and Sally Kornbluth The BCL-2 Family Proteins ? Key Regulators and Effectors of Apoptosis 69 David L Vaux BH3-only Proteins 75 Lina Happo, Andreas Strasser and Clare L Scott Mitochondrial Outer Membrane Permeabilization 90 Melissa J Parsons and Douglas R Green Mitochondria Fusion and Fission 97 Giovanni Benard, Guihong Peng and Mariusz Karbowski Death Receptors 110 Peter H Krammer and Inna N Lavrik Death Receptors at the Molecular Level: Therapeutic Implications 117 Marion MacFarlane Death Receptor-induced Necroptosis 127 Wim Declercq, Franky Van Herreweghe, Tom Vanden Berghe and Peter Vandenabeele Inhibitor of Apoptosis (IAP) and BIR-containing Proteins 138 David L Vaux Structures, Domains and Functions in Cell Death (DD, DED, CARD, PYD) 147 Hao Wu and Yu-Chih Lo Structure and Function of IAP and Bcl-2 Proteins 156 Mark G Hinds, Peter D Mace and Catherine L Day Engulfment of Apoptotic Cells and its Physiological Roles

165 Rikinari Hanayama, Masanori Miyanishi, Hiroshi Yamaguchi, Jun Suzuki and Shigekazu Nagata Autophagy 175 Mar??a Isabel Colombo and Hans-Uwe Simon Autophagy in Nonmammalian Systems 189 Jahda H Hill and Eric H Baehrecke Apoptosis: Regulatory Genes and Disease 197 James E Vince and John Silke Caspases in Inflammation and Immunity 212 Philippe M LeBlanc and Maya Saleh Immunity, Granzymes and Cell Killing 223 Nigel J Waterhouse, Olivia Susanto, KarinASedelies and Joseph A Trapani P53 and Cell Death 230 Kamil Wolyniec, Sue Haupt and Ygal Haupt Cornification of the Skin: A Non-apoptotic Cell Death Mechanism 240 E Candi, RA Knight and G Melino v Apoptosis: Inherited Disorders 253 Helen C Su and Michael J Lenardo From Reactive Oxygen and Nitrogen Species to Therapy 262 ScottRMcKercher, Tomohiro Nakamura and Stuart A Lipton Microbial Inhibitors of Apoptosis 272 Georg Ha?cker Drug Discovery in Apoptosis 282 Tom O?Brien and Vishva M Dixit.