Restoring human motor and cognitive function has been a fascinating research area during the last century. Interfacing the human nervous system with electro-mechanical rehabilitation machines is facing its crucial passage from research to clinical practice, enhancing the potentiality of therapists, clinicians and researchers to rehabilitate, diagnose and generate knowledge. The 2012 International Conference on Neurorehabilitation (ICNR2012, www.icnr2012.org) brings together researchers and students from the fields of Clinical Rehabilitation, Applied Neurophysiology and Biomedical Engineering, covering a wide range of research topics: · Clinical Impact of Technology· Brain-Computer Interface in Rehabilitation· Neuromotor & Neurosensory modeling and processing· Biomechanics in Rehabilitation· Neural Prostheses in Rehabilitation· Neuro-Robotics in Rehabilitation· Neuromodulation This Proceedings book includes general contributions from oral and poster sessions, as well as from special sessions. A section is also dedicated to pre-post conference workshops, including invited contributions from internationally recognized researchers. A selection of most relevant papers have been considered for publication in international journals (e. g. AJPM&R, JNER, JACCES), therefore they will appear soon in their extended versions in Special Issues.