The X-Men have taken down super-villains, aliens and their own future selves ... but never all at the same time! As Karima struggles to remember herself, Rachel comes to terms with her relationship with Sublime, and a new member joins the team, longtime X-foe Lady Deathstrike returns! And she has put together an all new Sisterhood, her own illuminati to take down the X-Men and enslave the world. And Psylocke is first in the Sisterhood's crosshairs! Recruiting the likes of Typhoid Mary and Enchantress, Deathstrike's cabal go on a global hunt for the most powerful ally of all ... an enemy who holds the X-Men responsible for her near-destruction! But when this foe awakens, neither team might be able to handle her!