Thanks to remarkable methodological and statistical advances in recent years, Single-Case design (SCD) research has become a viable and often essential option for researchers in applied psychology, education, and related fields. This text is a compendium of information and tools for researchers considering SCD research, a methodology in which one or several participants comprise a systematically-controlled experimental intervention study. SCD is a highly flexible method of conducting applied intervention research where it is not feasible or practical to collect data from traditional groups of participants. Initial chapters lay out the key components of SCDs, from articulating dependent variables to documenting methods for achieving experimental control and selecting an appropriate design model. Subsequent chapters show when and how to implement SCDs in a variety of contexts and how to analyze and interpret results. This book emphasizes key design and analysis tactics, such as randomization, to help enhance the internal validity and scientific credibility of individual studies. This book also includes in-depth descriptions of large-scale SCD research projects being undertaken at key institutions ; practical suggestions from journal editors on how to get SCD research published and detailed instructions for free, user-friendly, web-based randomization software.