This book describes a paradigm change in modern physics from the philosophy and mathematical expression of the quantum theory to those of general relativity. The approach applies to all domains - from elementary particles to cosmology. The change is from the positivistic views in which atomism, nondeterminism and measurement are fundamental, to a holistic view in realism, wherein matter - electrons, galaxies, - are correlated modes of a single continuum, the universe. A field that unifies electromagnetism, gravity and inertia is demonstrated explicitly, with new predictions, in terms of quaternion and spinor field equations in a curved spacetime. Quantum mechanics emerges as a linear, flatspace approximation for the equations of inertia in general relativity.