Íso Perdido, a young Guatemalan woman, works at a fertility clinic at Ixchel, named for the Mayan goddess of creation and destruction. Íso tends to the rich women who visit the clinic for the supposed conception-enhancing properties of the local lake. She is also the lover of Dr. Mann, the American doctor in residence. When an accident forces the doctor to leave Guatemala abruptly, Íso is abandoned, pregnant. After the birth, tended to by the manager of the clinic, the baby disappears. Determined to reclaim her daughter, Íso follows a trail north, eventually crossing illegally into a United States where the rich live in safe zones, walled away from the indigent masses. Traveling without documentation, and with little money, Íso must penetrate this world, and in this place of menace and shifting boundaries, she must determine who she can trust and how much, aware that she might lose her daughter forever.