In sixteenth-century Venice, in an island monastery, a cloistered monk experiences the adventure of a lifetime - all within the confines of his cell. Part historical fiction, part philosophical mystery, A Mapmaker's Dream tells the story of Fra Mauro and his struggle to realize his life's work: to make a perfect map - one that represents the full breadth of Creation.

News of Mauro's project attracts explorers, pilgrims, travelers, and merchants, all eager to contribute their accounts of faraway people and places. As he listens to the tales of the strange and fantastic things they've seen, Mauro comes to regard the world as much more than continents and kingdoms: that it is also made up of a vast and equally real interior landscape of beliefs, aspirations, and dreams. Mauro's map grows and takes shape, becoming both more complete and more incomprehensible.

In the process, the boundaries of Mauro's world are pushed to the extreme, raising questions about the relationship between representation, imagination, and the nature of reality itself.