Labelling of small biomolecules using novel technetium-99m cores

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May 14, 2021 | History

Labelling of small biomolecules using novel technetium-99m cores

Technetium-99m radiopharmaceuticals account for nearly 80% of all diagnostic studies done in nuclear medicine. The ability to determine the exact molecular structure of the coordination compounds by using modern powerful analytical tools such as NMR, mass spectroscopy and X ray diffraction has contributed to the understanding of the structure-activity relationships underlying the biological behavior of Tc-99m agents. Consequently, careful design of new ligands and their Tc-99m complexes led to the discovery of imaging agents for perfusion in the myocardium and brain, thereby extending the scope of diagnostic imaging using Tc-99m radiopharmaceuticals. Based on the new developments in Tc chemistry, there is good scope for the development of new radiopharmaceuticals for imaging cancer as well as certain specific disease conditions. The IAEA organized a Coordinated Research Project (CRP) with the specific objective to develop labelled biomolecules with the novel Tc-99m metal cores such as the Tc-99m-Carbonyl, Tc-99m-Nitrido, Tc-99m (4+1) and Tc-99m-HYNIC cores. The preparation, quality assessment and biological evaluations of a large number of Tc-99m complexes with biomolecules such as RGD peptides, annexin derived peptides, fatty acid derivatives, quinazoline derivatives and glucose analogues were achieved by the participants during the CRP. The results obtained from the participating laboratories are summarized in this publication.--Publisher's description.

Publish Date
Language
English
Pages
311

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Edition Availability
Cover of: Labelling of small biomolecules using novel technetium-99m cores
Labelling of small biomolecules using novel technetium-99m cores
2007, International Atomic Energy Agency
in English

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Book Details


Table of Contents

pt. 1. Overview of the coordinated research project
pt. 2. Reports by the participants in the coordinated research project.

Edition Notes

"STI/DOC/010/459"--Title page verso.

Includes bibliographical references.

Also issued online.

Published in
Vienna, Austria
Series
Technical reports series -- no. 459, Technical reports series (International Atomic Energy Agency) -- no. 459.

Classifications

Dewey Decimal Class
539.7
Library of Congress
QC770 .I56 no.459

The Physical Object

Pagination
311 pages
Number of pages
311

ID Numbers

Open Library
OL32420164M
Internet Archive
labellingofsmall0000unse
ISBN 10
9201016077
ISBN 13
9789201016072
OCLC/WorldCat
191954428

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May 14, 2021 Created by ImportBot import new book