Estimates of the number and distribution of anadromous pacific salmon harvested by sport anglers in the Yukon River drainage are presented for the years 1977 through 1991. During this time period, the annual salmon sport harvest ranged from less than 1,000 fish to approximately 5,000 fish. Primary species harvested were chinook salmon Oncorhynchus tshawytscha, chum salmon Oncorhynchus keta, and coho salmon Oncorhynchus kisutch in near-equal proportions over the 15-year period. Sockeye salmon Oncorhynchus nerka and pink salmon Oncorhynchus gorbuscha were a negligible component of the sport harvest. The geographic distribution of harvests was heavily dominated by the Tanana River valley. Sport harvests of chinook salmon in the Salcha River were more numerous than those in the Chatanika and Chena rivers in most years, but in 1988 and 1989 the Salcha River sport harvest was relatively less than in previous years. Harvest estimates by species of salmon are provided for all sites in the Yukon River drainage for which anglers reported harvesting salmon in response to annual statewide harvest surveys from 1977 through 1991.