An edition of ˜Theœ brain's best friend (2013)

˜Theœ brain's best friend

microglial neurotoxicity revisited

˜Theœ brain's best friend
Sabine Hellwig, Sabine Hellwig
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Last edited by MARC Bot
April 26, 2022 | History
An edition of ˜Theœ brain's best friend (2013)

˜Theœ brain's best friend

microglial neurotoxicity revisited

Abstract: One long standing aspect of microglia biology was never questioned; their involvement in brain disease. Based on morphological changes (retracted processes and amoeboid shape) that inevitably occur in these cells in case of damage in the central nervous system, microglia in the diseased brain were called “activated.” Because “activated” microglia were always found in direct neighborhood to dead or dying neuron, and since it is known now for more than 20 years that cultured microglia release numerous factors that are able to kill neurons, microglia “activation” was often seen as a neurotoxic process. From an evolutionary point of view, however, it is difficult to understand why an important, mostly post-mitotic and highly vulnerable organ like the brain would host numerous potential killers. This review is aimed to critically reconsider the term microglia neurotoxicity and to discuss experimental problems around microglia biology, that often have led to the conclusion that microglia are neurotoxic cells

Publish Date
Publisher
Universität
Language
English

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Book Details


Edition Notes

Frontiers in cellular neuroscience. 7 (2013), 71, DOI 10.3389/fncel.2013.00071, issn: 1662-5102

IN COPYRIGHT http://rightsstatements.org/page/InC/1.0 rs

Archivierung/Langzeitarchivierung gewährleistet

Published in
Freiburg

Classifications

Dewey Decimal Class
616.83

The Physical Object

Pagination
Online-Ressource

ID Numbers

Open Library
OL37839588M
Deutsche National Bibliothek
1134883668

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