The city of knowledge is a concept that has evolved over the last decades, integrating various economic theories and modes of production, to form a precept that incorporates several elements, among which are the relevance of human capital formation, the importance of innovation, the equitable dissemination of knowledge, while emphasizing an adequate ecological balance sheet. Together these factors must be combined in such a way as to generate sustainable communities in which their inhabitants have environments that allow them to develop fully. This book, which represents the efforts of a team of academics from the Instituto Politécnico Nacional, it seeks to generate a proposal to build indicators that allow to measure the progress of Mexico City in different variables representative of a digital city and knowledge, in such a way that they are comparable nationally and internationally, in addition to being projectable in different scenarios. With these indicators it is also possible to generate public policy proposals. The results lead us to reflect on the broad effort we must still make in an integral way, as a nation and city, to drive economies and cities of knowledge.