"The caveats of drug-eluting stents"

a critical appraisal of the safety concerns

"The caveats of drug-eluting stents"
Joost Daemen, Joost Daemen
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Last edited by MARC Bot
December 22, 2022 | History

"The caveats of drug-eluting stents"

a critical appraisal of the safety concerns

Coronary heart disease has been the leading cause of death in developed countries for many years. At the same time, the developments in the field of interventional cardiology occurred at an incredible speed and it took no more than 15 years for the first balloon-mounted stent by Palmaz et al. in 1985 to evolve into a modern first generation drug-eluti ng stent (DES). As early as 1999, stenting comprised 84.2% of percutaneous coronary interventions (PCI). In the same year, several preclinical studies reported that sirolimus (rapamycin), a macrocyclic lactone that inhibits cytokine-mediated and growth-factormediated proliferation of lymphocytes and smooth-muscle cells, reduced neointimal proliferation (i.e. renarrowing of the vascular lumen at the site of stent implantation, leading to recurrence of angina - the largest limitation of stenting thus far). In 2002, the first DES, coated with sirolimus, were introduced into clinical practice in order to reduce restenosis which occurred in 15% to 25% of patients receiving bare-metal stents.6, 7 Subsequent trials with different types of DES confirmed their efficacy in this regard.8 In 2002, the pivotal RAVEL trial reported that none of the patients in the sirolimus-stent group, as compared with 26.6% of those in the standard-stent group, had restenosis of 50 percent or more of the luminal diameter (P<0.001)..

Publish Date
Publisher
s.n.]
Language
English
Pages
384

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Book Details


Edition Notes

Proefschrift Erasmus Universiteit Rotterdam.

Includes bibliographical references.

Published in
[S.l

The Physical Object

Pagination
384 p.
Number of pages
384

ID Numbers

Open Library
OL44787020M
ISBN 10
9071382648
ISBN 13
9789071382642
OCLC/WorldCat
276763583

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December 22, 2022 Created by MARC Bot import new book