The book first establishes a theoretical framework for conceptualizing environmental analysis. It then develops a conception of environmental literature with an emphasis on works by women, arguing for the need to reconceptualize woman/nature and nature/culture associations, and critiquing the problems of male poetic sex-typing of the planet. Murphy also elaborates on specific works and authors, with an emphasis on literary texts by Hampl, Harjo, Snyder, and Le Guin.

Additionally, he treats issues of canon and pedagogy, as well as the possibility of agency in a postmodern era.

Ranging across diverse fields and incorporating cultural studies, post-structuralist literary theory, and ecofeminist philosophy, Literature, Nature, and Other both defines and critiques the current terrains of literary ecocriticism and nature writing/environmental literature. Literary examples are drawn from fiction, poetry, and prose, including postmodern metanarratives and works by Native Americans and Chicanas.