Frei Luís de Sousa is a play in three acts by Portuguese playwright Almeida Garrett, premiered on 4 July 1843 and first published the following year. A classical tragedy, it is loosely based on the true story of a 16th-century nobleman who, after being presumed killed in battle, returns to Portugal under Spanish rule, to the consternation of his wife who has since remarried.

Frei Luís de Sousa is considered Almeida Garrett's dramatic masterpiece and the archetype of Portuguese Romantic theatre.

Frei Luís de Sousa é um drama em três atos de Almeida Garrett, estreado em 1843 e publicado em 1844 com notas do autor, baseado livremente na vida de Frei Luís de Sousa, nome adotado pelo frade Manuel de Sousa Coutinho.