A phone call in the night, an unexpected diagnosis, a shocking revelation - suddenly life can change forever. Sandra, Colleen and Jude have been friends for nearly a lifetime. They share sexual secrets, decorating tips, advice on marriage, even a hairdresser. Despite their differences and occasional snarls, their friendship only grows stronger over time, and their partners, Jack, Richard, and Gus, go along with it, letting it shape their own lives. Now, with Sandra's crisis, everyone must find a way to endure the present and to imagine the future.