4 halfsisters meet at the sickbed of their domineering and mostly absent father. The 4 women of different generation, background, religion and sexual orientation seem to have nothing more in common than the genes of Stephen Upton. During their stay, however they find out they may need sisterhood more than they would ever thought possible. Elizabeth, the oldest, is succesfull in her career, but one can't say the same thing for her personal life. She remains unmarried, and has only ever been in love with a man out of her reach. Mary, the second daughter, accomplished quite the opposite. She has married multiple times in search for... For what actually? but has only found love in the arms of her last husband, who was killed in an accident. Alex is the 3rd daughter, married with children, she is easily mistaken for a naiv housewife, but there is more to her than one might think. And then there is the young Ronnie, the daughter of the chicana housekeeper who has the upton blue eyes. As time passes the sisters find out they have more in common than a father, or even the horrible secret he has laid upon every one of them...