With the scent of prey in his nostrils, infamous bounty hunter, Iron Eyes, has gone, leaving Squirrel Sally alone in a remote town. But Sally is not that easily abandoned, and sets out after him, whipping her six horses furiously in pursuit. As Iron Eyes closes in on outlaws Joe Hyams and Buster Jones, deep in the dangerous terrain, Sally realizes that there is another chasing Iron Eyes: the one-armed Wolfe is also hot on his heels.