Despair Vol. 1 includes two main graphic narratives, rendered in Dockery's distinctive illustration style, that display his penchant for dark, non-linear story-lines, as well as a series of drawings inspired by the 19th century poet Stephen Crane. The book also features work by the artist Chris Wright and end-pages designed by Julia Gfrörer.

Despair Vol. 2 is an exegesis on the titular topic, with each volume featuring curated guest artists invited to meditate/elucidate in sequential black and white comix form how she or he processes the various ways in which doom trips invade our human experience. Special guests include: Robert Beatty, Max Clotfelter, Dunja Jankovic, Matt Minter, Mark Rudolph.