Locas tells a violent and poignant story set in the heart of the rough L.A. neighborhood Echo Park. Lucia and Cecilia are the girlfriend and sister of the rising young loco whose gun trade is about to explode into the big business of drugs. When their world starts to split apart under the vicious pressure of gang warfare, Lucia seizes her chance: she builds her own private cadre of Fire Girls and rises to become a gangster in her own right.

Cecilia, devastated by a miscarried pregnancy and bittersweet love for another woman, leaves the gang for the Catholic church. Yxta Maya Murray has created a richly textured story from the tragedies of Lucia and Cecilia's loves, rages, and betrayals, never once avoiding the larger tragedy of their entrapment in a feudal and dangerous world.