Lost Highway spans the years between World War II and the Vietnam era to tell the story of an artist and his divided life. In the early days of modern country music, Reeves and his group travel the back roads of the Appalachian South, searching for an audience that will understand the power and grace of their music.

Leaving his wife and son at home and virtually penniless in the small town of Maxwell, West Virginia, Reeves finds that his talent is as underappreciated as the country he travels through, a realization that precipitates a crisis of faith and personal vision that devastates his marriage and career.

Years later, when his son returns from Vietnam both physically and emotionally maimed, the family faces a turning point that ultimately serves to reunite them - and guides Reeves to a rediscovery of himself as a man and as a musician.