MARC Record from Library of Congress

LEADER: 02095cam a22003857a 4500
001 2011293620
003 DLC
005 20150121080305.0
008 111208s2012 enka b 001 0 eng d
010 $a 2011293620
015 $aGBB198738$2bnb
016 7 $a015873824$2Uk
020 $a9780123751386 (hbk)
020 $a0123751381 (hbk)
035 $a(OCoLC)ocn759821822
040 $aAU@$beng$cAU@$dCDX$dMMU$dDLC
042 $alccopycat
050 00 $aRM666.N87$bN45 2012
060 4 $aQU 58$bN397t 2012
082 04 $a615.36$223
100 1 $aNeidle, Stephen.
245 10 $aTherapeutic applications of quadruplex nucleic acids /$cStephen Neidle.
250 $a1st ed.
260 $aLondon ;$aWaltham, MA :$bElsevier/Academic Press,$c2012.
300 $axii, 196 p. :$bill. ;$c24 cm.
520 $a"Therapeutic applications of quadruplex nucleic acids provides a single comprehensive survey that describes and assesses recent advances in quadruplex therapeutics and targeting strategies. It also covers the underlying fundamentals of such topics as quadruplex structure, small-molecule recognition, biological roles of genomic quadruplexes, and quadruplex informatics"--P. [4] of cover.
504 $aIncludes bibliographical references and index.
505 0 $aIntroduction: quadruplexes and their biology -- DNA and RNA quadruplex structures -- The structures of human telomeric DNA quadruplexes -- Telomeric quadruplex ligands I: anthraquinones and acridines -- Telomeric quadruplex ligands II: polycyclic and non-fused ring compounds -- The biology and pharmacology of telomeric quadruplex ligands -- Genomic quadruplexes as therapeutic targets -- RNA quadruplexes -- Design principles for quadruplex-binding small molecules -- The determination of quadruplex structures.
650 0 $aQuadruplex nucleic acids$xTherapeutic use.
650 12 $aG-Quadruplexes.
650 12 $aAntineoplastic Agents$xtherapeutic use.
650 22 $aAntineoplastic Agents$xpharmacology.
650 22 $aNeoplasms$xdrug therapy.
650 22 $aNucleic Acid Conformation.
650 22 $aTelomere$xchemistry.