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Previews available in: English
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Bace: Lead Target for Orchestrated Therapy of Alzheimer's Disease
2010, Wiley & Sons, Incorporated, John
in English
047059408X 9780470594087
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BACE: lead target for orchestrated therapy of Alzheimer's disease
2010, John Wiley & Sons
in English
047029342X 9780470293423
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Book Details
Table of Contents
BACE : APP processing, and signal transduction in Alzheimer's disease (AD) / Dale E. Bredesen and Edward H. Koo
Identification of BACE as an AD target / Robert L. Heinrikson and Sukanto Sinha
BACE biological assays / Alfredo G. Tomasselli and Michael J. Bienkowski
Peptidic, peptidomimetic, and HTS based BACE inhibitors / James P. Beck and Dustin J. Mergott
Fragment-based approaches for identification of BACE inhibitors / Andreas Kuglstatter and Michael Hennig
Structure-based drug design of BACE inhibitors : technical and practical aspects of preparation, 3-dimensional structure, and computational analysis / Felix F. Vajdos, Veer Shanmugasundaram, and Alfredo G. Tomasselli
Pharmacological models for preclinical testing : from mouse to dog to non-human primates / Jason L. Eriksen, Michael Paul Murphy, and Elizabeth Head
Adsorption, distribution, metabolism, excretion (ADME), efficacy & toxicology for BACE inhibitors / Ishrut Hussain and Emmanuel Demont
Clinical trials for disease modifying drugs such as BACE inhibitors / Henry Hsu
Future strategies for development of novel BACE inhibitors : anti-APP e-site antibody & APP binding small molecule approaches for Alzheimer's disease / Beka Solomon ... [et al.].
Edition Notes
Includes bibliographical references and index.
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