An edition of Drug safety evaluation
(2011)
Drug safety evaluation
methods and protocols
by Jean-Charles Gautier
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| Edition | Availability |
|---|---|
1
Drug Safety Evaluation: Methods and Protocols
2018, Springer New York
in English
1493984063 9781493984060
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2
Drug Safety Evaluation: Methods and Protocols
Jul 27, 2017, Humana
hardcover
1493971700 9781493971701
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3
Drug Safety Evaluation: Methods and Protocols
2016, Humana Press
in English
1493956698 9781493956692
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zzzz
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4
Drug safety evaluation: methods and protocols
2011, Humana Press
in English
1603271864 9781603271868
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aaaa
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Book Details
Table of Contents
Part I. General toxicology. Developing combination drugs in preclinical studies / Alberto Lodola. Preclinical evaluation of juvenile toxicity / Paul C. Barrow, Stéphane Barbellion, and Jeanne Stadler
Part II. Pathology. Necropsy and sampling procedures in rodents / Laurence Fiette and Mohamed Slaoui. Histopathology procedures : from tissue sampling to histopathological evaluation / Mohamed Slaoui and Laurence Fiette. Principles and methods of immunohistochemistry / José A. Ramos-Vara. Tissue microarrays and digital image analysis / Denise Ryan, Laoighse Mulrane, Elton Rexhepaj, and William M. Gallagher
Part III. Genetic toxicology. Micronucleus assay and labeling of centromeres with FISH technique / Ilse Decordier, Raluca Mateuca, and Micheline Kirsch-Volders. The use of bacterial repair endonucleases in the comet assay / Andrew R. Collins
Part IV. Safety pharmacology. Manual whole-cell patch-clamping of the HERG cardiac K⁺ channel / Xiao-Liang Chen, Jiesheng Kang, and David Rampe
Part V. Investigative toxicology. Generation and analysis of transcriptomics data / Philip D. Glaves and Jonathan D. Tugwood. Protocols of two-dimensional difference gel electrophoresis to investigate mechanisms of toxicity / Emmanuelle Com, Albrecht Gruhler, Martine Courcol, and Jean-Charles Gautier. Protocols and applications of cellular metabolomics in safety studies using precision-cut tissue slices and carbon 13 NMR / Gabriel Baverel, Sophie Renault, Hassan Faiz, Maha El Hage, Catherine Gauthier, Agnès Duplany, Bernard Ferrier, and Guy Martin. Statistical analysis of quantitative RT-PCR results / Richard Khan-Malek and Ying Wang. Evaluation of mitochondrial respiration in cultured rat hepatocytes / Jean-Pierre Marchandeau and Gilles Labbe
Part VI. Screening assays for developmental toxicity. FETAX assay for evaluation of developmental toxicity / Isabelle Mouche, Laure Malesic, and Olivier Gillardeaux. Evaluation of embryotoxicity using the zebrafish model / Lisa Truong, Stacey L. Harper, and Robert L. Tanguay
Part VII. Chemical protein adducts. Protocols of in vitro protein covalent binding studies in liver / Jean-François Lévesque, Stephen H. Day, and Allen N. Jones. Utilization of MALDI-TOF to determine chemical-protein adduct formation in vitro / Ashley A. Fisher, Matthew T. Labenski, Terrence J. Monks, and Serrine S. Lau. Utilization of LC-MS/MS analyses to identify site-specific chemical protein adducts in vitro / Ashley A. Fisher, Matthew T. Labenski, Terrence J. Monks, and Serrine S. Lau. One-dimensional western blotting coupled to LC-MS/MS analysis to identify chemical-adducted proteins in rat urine / Matthew T. Labenski, Ashley A. Fisher, Terrence J. Monks, and Serrine S. Lau. Identification of chemical-adducted proteins in urine by multi-dimensional protein identification technology (LC/LC-MS/MS) / Matthew T. Labenski, Ashley A. Fisher, Terrence J. Monks, and Serrine S. Lau
Part VIII. Safety biomarkers. Optimization of SELDI for biomarker detection in plasma / Jean-Francois Léonard, Martine Courcol, and Jean-Charles Gautier. Differential proteomics incorporating iTRAQ labeling and multi-dimensional separations / Ben C. Collins, Thomas Y.K. Lau, Stephen R. Pennington, and William M. Gallagher. NMR and MS methods for metabonomics / Frank Dieterle, Björn Riefke, Götz Schlotterbeck, Alfred Ross, Hans Senn, and Alexander Amberg. Absolute quantification of toxicological biomarkers by multiple reaction monitoring / Thomas Y. K. Lau, Ben C. Collins, Peter Stone, Ning Tang, William M. Gallagher, and Stephen R. Pennington.
Edition Notes
Includes bibliographical references and index.
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